Bet the MLB run line when you think a favorite wins by 2+ runs or an underdog loses by 1 or wins outright. Bet the moneyline for any other side selection. Heavy favorites usually have better EV on the run line (-1.5 at +100 to +130); plus-money dogs usually have better EV on the moneyline.
The MLB run line is almost always set at ±1.5 runs. The favorite at -1.5 must win by 2+. The underdog at +1.5 covers by winning outright OR losing by exactly 1 run. The moneyline is the straight pick on who wins.
Bet the run line on heavy favorites when you think they win by 2+ at least 50%+ of the time (run line -1.5 at +100 to +130 beats moneyline at -200+). Bet the moneyline on plus-money dogs because the upside is bigger and the run line cap of +1 isn't worth giving up.
Heavy favorite example: Team A is -200 ML / -1.5 RL +110.
Per dollar wagered: ML hits 70% with profit of $50 per win → $35 expected per $100 wagered. RL hits 52% with profit of $110 per win → $57 expected per $100 wagered. RL wins by ~$22 per $100 wagered.
The model produces probability + EV for both ML and RL on every game. The pick published is whichever market has the higher EV after model-vs-market blend. For most games, the EV difference is small (0.5-1.5%) and either market is acceptable. For games where EV difference exceeds 2%, the model strongly prefers one market over the other. The daily picks page shows which market and why.
Bet the MLB run line when you think a favorite wins by 2+ runs (RL -1.5 at +100-+130 beats moneyline at -200+) or an underdog loses by 1 or wins outright (RL +1.5 at -150-160 captures both outcomes). Bet the moneyline for plus-money dogs above +130 (better upside than RL cap) and mild favorites (-110 to -140 ML where RL prices balloon).
The run line is better than the moneyline for HEAVY favorites (ML -180 or worse) when RL -1.5 prices are +100 to +130 AND the favorite has 50%+ probability of winning by 2+. The moneyline is better for mild favorites (-110 to -140) because RL -1.5 prices balloon to +180+ when the favorite isn't favored enough.
Best MLB run line strategy: target heavy favorites at home in pitcher mismatches or hitter parks with offensive lineup edges (RL -1.5 at +100-130). Target plus-money dogs in tight pitcher duels where 1-run losses are common (RL +1.5 at -150-160). Avoid RL -1.5 on mild favorites and RL +1.5 on heavy dogs.
MLB favorites cover -1.5 about 38-44% of the time on average across all favorite tiers. Heavy favorites (-200+ ML) cover -1.5 at ~50-55% rate; mild favorites (-130 ML) cover ~35-40% rate. The cover rate scales with favorite size, which is why heavy favorites have better RL EV than mild ones.
MLB run line bets are profitable for sharp bettors who target the right matchup types (heavy favorites in pitcher mismatches, dogs in tight pitcher duels). Random RL selection loses to vig; selective RL betting yields 3-6% ROI for sharp models. RL markets are slightly more efficient than 5 years ago but still have spots where the public underweights the favorite's tendency to pull away late.